Morphogenesis of the anterior segment in the zebrafish eye |
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Authors: | Kelly?A?Soules Email author" target="_blank">Brian?A?LinkEmail author |
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Institution: | (1) Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA |
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Abstract: | Background The ocular anterior segment is critical for focusing incoming light onto the neural retina and for regulating intraocular
pressure. It is comprised of the cornea, lens, iris, ciliary body, and highly specialized tissue at the iridocorneal angle.
During development, cells from diverse embryonic lineages interact to form the anterior segment. Abnormal migration, proliferation,
differentiation, or survival of these cells contribute to diseases of the anterior segment such as corneal dystrophy, lens
cataract, and glaucoma. Zebrafish represent a powerful model organism for investigating the genetics and cell biology of development
and disease. To lay the foundation for genetic studies of anterior segment development, we have described the morphogenesis
of this structure in zebrafish. |
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Keywords: | |
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