X-chromosome inactivation and escape |
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| Authors: | CHRISTINE M DISTECHE JOEL B BERLETCH |
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| Institution: | 1. Department of Pathology, University of Washington, Seattle, WA, 98195, USA
2. Department of Medicine, University of Washington, Seattle, WA, 98195, USA
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| Abstract: | X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field. |
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