Accumulation of O-methyl-L-homoserine by methanol-utilizing bacteria |
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Authors: | Y Tanaka K Araki K Nakayama |
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Institution: | (1) Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, 194 Tokyo, Japan |
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Abstract: | Summary Several classes of mutants derived from facultative methylotrophs, Microcyclus eburneus and Protaminobacter ruber, accumulate 0.5–3.8 mg/ml of O-methyl-L-homoserine (OMH) in a medium containing methanol as sole carbon source. The wild-type parent strains also accumulate OMH when the medium is supplemented with L-homoserine; the accumulation of OMH by the mutants is ascribed to an increased L-homoserine pool. |
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