Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1. |
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| Authors: | N Imai S Kaneda Y Nagai T Seno D Ayusawa F Hanaoka F Yamao |
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| Affiliation: | National Institute of Genetics, Mishima, Japan. |
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| Abstract: | A cDNA encoding the ubiquitin-activating enzyme, E1, was isolated from the mouse mammary carcinoma cell line, FM3A, and shown to complement mutant mouse cells deficient in the enzyme. The 3495-bp cDNA encodes 1058 amino acids (aa), and shares extensive homology with the human E1 enzyme at both the nucleotide and aa sequence levels. |
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