| 呼吸道合胞病毒非结构蛋白NS1、NS2的研究进展 |
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| 引用本文： | 卜选运.呼吸道合胞病毒非结构蛋白NS1、NS2的研究进展[J].生物技术通报,2011,0(5). |
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| 作者姓名： | 卜选运 |
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| 作者单位： | 昆明理工大学生命科学与技术学院,昆明,650224 |
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| 摘 要： | 呼吸道合胞病毒(reespiratory syncytial virus,RSV)是引起婴幼儿和老年人下呼吸道感染的重要病原体之一.由于该病毒的致病机理还不太清楚导致目前尚无有效治疗RSV的方法.研究表明,呼吸道合胞病毒的非结构蛋白NS1、NS2具有抗细胞凋亡的作用,同时可以逃避宿主免疫系统(IFN)对病毒的干扰,有利于病毒复制.敲除这两种基因的减毒活疫苗和袁达沉默NS1的小干扰RNA(siRNA)的质粒研究已经取得了一定的进展.对非结构蛋白功能的深入研究有助于了解RSV的致病机理,同时为预防和治疗RSV感染奠定理论基础.
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| 关 键 词： | 呼吸道合胞病毒 减毒活疫苗 |
Research Development of RSV Nonstructural Proteins NS1 and NS2 |
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| Bu Xuanyun.Research Development of RSV Nonstructural Proteins NS1 and NS2[J].Biotechnology Bulletin,2011,0(5). |
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| Authors: | Bu Xuanyun |
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| Institution: | Bu Xuanyun(College of Life Sciences,Kunming University of Science and Technology,Kunming 650224) |
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| Abstract: | Human respiratory syncytial virus(RSV) is one of the most important pathogen of serious respiratory tract illness in infants and children as well as old people.The way of how to lead to disease is still not very clear now,so that we still don't know how to therapy the RSV infection.The research proved that RSV nonstructural proteins NS1 and NS2 suppress premature apoptosis and escape from the IFN to protect to benefit for the replication of virus.The RSV vaccine of which is attenuated by deleted NS gene and... |
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| Keywords: | NS1 NS2 IFN siRSV-NS1 |
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