Changes in calmodulin level after fertilization and during first cleavage in the egg of the urodelan amphibian Pleurodeles waltlii |
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| Authors: | Claude Louis Gallien Jacqueline Weinman Dominique Rainteau Serge Weinman |
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| Institution: | 1. Laboratoire de Biologie du développement, UER Etudes Médicales et Biologiques, Université René Descartes, 75270 Paris Cedex 06, France;2. Laboratoire de Biochimie, UER Biomédicale des Saints-Pères, Université René Descartes, 75270 Paris Cedex 06, France |
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| Abstract: | We report three significant calmodulin rises related to Pleurodeles waltlii egg fertilization and following developmental events. These elevations are correlated to the major obvious Ca2+-dependent events: Na+-H+ exchange, activation of NAD kinase, triggering of cortical reaction, resumption of meiotic division II, initiation of DNA synthesis and regulation of cell division. Therefore, it is suggested that alterations in calmodulin level in fertilized egg may be part of the Ca2+-dependent regulatory mechanisms which turn on metabolisms, initiate development and govern cell cleavages. |
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| Keywords: | To whom offprint requests should be sent Address: Laboratoire de Biologie du Développement 45 rue des Saint-Pères 75270 Paris Cedex 06 France |
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