Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines |
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| Authors: | R. Ramajayam Rajani Giridhar Mange Ram Yadav Hakim Djaballah David Shum Constantin Radu |
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| Affiliation: | 1. Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, 390 001, India;2. HTS Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 487, New York, NY, 10583, USA |
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| Abstract: | Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined. |
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| Keywords: | diaryldiazepines diarylpyrimidines antiproliferative activity |
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