|
|||||
|
|
The convenient synthesis and evaluation of the anticancer activities of new resveratrol derivatives |
|
| Authors: | Hyung-In Moon Ill-Min Chung Jae-Chul Jung Eunyoung Lim Yongnam Lee |
| Affiliation: | 1. Department of Neuroscience and, Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Kyunggido 435-040, South Korea;2. Department of Applied Life science, Kon Kuk University, Seoul 143-701, South Korea;3. Department of Neuroscience and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea;4. Department of Chemistry, Yonsei University, Seoul, 120-749 South Korea |
| Abstract: | In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 13–22. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC50 of 5.7 μM – 11.4 μM in vitro. |
| Keywords: | Stilbene derivatives Wadsworth-Horner-Emmons reaction anticancer activity |