Synthesis of new bisaryl cyclopentathiophene and thieno-cyclopentoxazolidine derivatives as potential cytotoxic agents |
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| Authors: | Ziad Omran Patrick Dallemagne Sylvain Rault |
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| Affiliation: | Centre d'Etudes et de Recherche sur le Médicament de Normandie UFR des Sciences Pharmaceutiques, Université de Caen Basse Normandie, 5 rue Vaubénard, 14032, Caen cedex, France |
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| Abstract: | ![]()
The synthesis of new bisaryl thienocyclopentoxazolidine derivatives was achieved through a Suzuki cross-coupling procedure with the aim to enhance the previously reported cytotoxicity of the series. The biological activity, evaluated in the NCI's in vitro human disease-oriented tumor cell line screening panel, was however partially conserved by the pharmacomodulations. |
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| Keywords: | Thiophene cyclopentane oxazolidine Suzuki cross-coupling cytotoxicity |
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