Synthesis and Cytotoxic Activity of Thiazolofluorenone Derivatives |
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| Authors: | Hadjila Chabane Alain Pierre Stephane Leonce Bruno Pfeiffer Pierre Renard |
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| Affiliation: | 1. Groupe de Chimie Organique, Laboratoire de Biotechnologies et de Chimie Bio-organique, FRE 2766, Université de La Rochelle, Avenue Michel Crépeau, 17042, La Rochelle, France;2. Institut de Chimie, Organique et Analytique, UMR-CNRS 6005, Université d' Orléans, rue de Chartres, BP 6759, F-45067, Orléans cedex 2, France;3. Division de Cancérologie Expérimentale, Institut de Recherche Servier, 125 chemin de Ronde, 78290, Croissy sur Seine, France;4. Laboratoires Servier, 1 Rue Carle Hébert, 92415, Courbevoie cedex, France |
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| Abstract: | The synthesis and biological evaluation of some novel thiazolofluorenones, thiazolofluorenes and thiazoloanthraquinones, substituted with amino side-chains are described. These polyheterocyclic compounds have been synthesized via the corresponding imino-1,2,3-dithiazoles. Their cytotoxic activity and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukaemia cell line. |
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| Keywords: | Imino-1,2,3-dithiazoles Fluorenones Thiazoles Cytotoxic activity 2-[4-(2-hydroxethyl)-piperazin-1-yl]ethanesulfonic acid (HEPES) Phosphate buffered solution (PBS) Ribonuclease (RNase) |
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