Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III |
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| Authors: | Alexandra Testard Laurent Picot Ingrid Fruitier-Arnaudin Jean-Marie Piot Hadjila Chabane Lisianne Domon |
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| Affiliation: | Laboratoire de Biotechnologie et Chimie Bio-organique, FRE CNRS 2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Université de la Rochelle, Batiment Marie Curie, F-17042, La Rochelle cedex 1, France |
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| Abstract: | ![]()
Novel 6-substituted thiazolocarbazole derivatives have been synthesized under microwave irradiation via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor potential of these polyheterocyclic compounds was evaluated. Among all the tested thiazolocarbazoles, compound 10 is the most effective in inhibiting cell growth. |
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| Keywords: | Microwave chemistry Imino-1,2,3-dithiazoles Appel salt Carbazoles Thiazoles Cytotoxic and antiproliferative activities |
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