In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds |
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| Authors: | Ismet Basaran Selma Sinan Umit Cakir Mustafa Bulut Oktay Arslan Ozen Ozensoy |
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| Affiliation: | 1. Department of Chemistry, Balikesir University Science &2. Art Faculty, CAGIS/Kampus, 10100, Balikesir, Turkey;3. Department of Biology, Balikesir University Science &4. Science and Art Faculty, Department of Chemistry, Marmara University, Kadik?y, 81040, Istanbul, Turkey |
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| Abstract: | ![]()
A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B. |
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| Keywords: | Carbonic anhydrase isozymes I and II inhibitors coumarin phenols cancer |
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