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Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation |
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| Authors: | Nisha Saxena Nimisha Singh Mridul Mishra G B Shiva Keshava Praveen Kumar Shukla Rama Pati Tripathi |
| Institution: | 1. Medicinal and Process Chemistry Division;2. Fermentation Technology Division, Central Drug Research Institute, Lucknow, 226001, India |
| Abstract: | A series of azatricyclodiones and octahydro-benzof]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the compounds (2) displayed moderate antitubercular activity while two compounds (2) and (4) inhibited the fungal growth at 25 μg/mL. |
| Keywords: | Cycloaddition dienophile furfuryl amine azatricyclodiones octahydro-benzo[f]isoindoles antimicrobials |