Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation |
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Authors: | Maria Rybczynska Adam Csordas |
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Institution: | (1) Department of Biochemistry, K. Marcinikowski Academy of Medicine, Poznan, Poland;(2) Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria |
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Abstract: | The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (100), lauric (120), myristic (140), oleic (cis-181) and elaidic (trans-181) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37°, but also at 42° and 47°C lauric acid (120) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis. |
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Keywords: | hypotonic hemolysis free fatty acids hyperthermia ionizing radiation erythrocyte membrane human |
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