An integrated linkage-radiation hybrid map of the canine genome |
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| Authors: | Cathryn S. Mellersh Christophe Hitte Melissa Richman Francoise Vignaux Catherine Priat Sophie Jouquand Petra Werner Catherine André Susan DeRose Donald F. Patterson Elaine A. Ostrander Francis Galibert |
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| Affiliation: | (1) Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., D4-100, P.O. Box 19024, Seattle, Washington 98109-1024, USA, US;(2) UPR 41 CNRS, Recombinaisons Génétiques, Faculté de Médecine, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cédex, France, FR;(3) Section of Medical Genetics and Center for Comparative Medical Genetics, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA, US |
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| Abstract: | ![]()
Purebred dogs are a unique resource for dissecting the molecular basis of simple and complex genetic diseases and traits. As a result of strong selection for physical and behavioral characteristics among the 300 established breeds, modern dogs are characterized by high levels of interbreed variation, complemented by significant intrabreed homogeneity. A high-resolution map of the canine genome is necessary to exploit the mapping power of this unusual resource. We describe here the integration of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate a map of 724 markers—the densest map of the canine genome described to date. Through the inclusion of 217 markers on both the linkage and RH maps, the 77 RH groups are reduced to 44 syntenic groups, thus providing comprehensive coverage of most of the canine genome. Received: 10 June 1999 / Accepted: 23 September 1999 |
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