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Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study |
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| Authors: | Michael B Coulthart Gerard H Jansen Elina Olsen Deborah L Godal Tim Connolly Bernard CK Choi Zheng Wang Neil R Cashman |
| Institution: | 1.Canadian Creutzfeldt-Jakob Disease Surveillance System,Public Health Agency of Canada,Winnipeg,Canada;2.Canadian Creutzfeldt-Jakob Disease Surveillance System,Public Health Agency of Canada,Ottawa,Canada;3.Department of Pathology and Laboratory Medicine,Eastern Ontario Regional Laboratory,Ottawa,Canada;4.Chronic Disease Surveillance and Monitoring Division, CCDPC, HPCDPB,Public Health Agency of Canada,Ottawa,Canada;5.Department of Epidemiology and Community Medicine,University of Ottawa,Canada;6.Shantou University Medical College,Shantou,China;7.Brain Research Centre and PrioNet Canada,University of British Columbia,Vancouver,Canada |
| Abstract: | BackgroundTo better characterize the value of cerebrospinal fluid (CSF) proteins as diagnostic markers in a clinical population of subacute encephalopathy patients with relatively low prevalence of sporadic Creutzfeldt-Jakob disease (sCJD), we studied the diagnostic accuracies of several such markers (14-3-3, tau and S100B) in 1000 prospectively and sequentially recruited Canadian patients with clinically suspected sCJD. |
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