Sesquiterpenes from the roots of Illicium dunnianum |
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| Institution: | 1. School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, People''s Republic of China;2. College of Chemistry & Pharmacy, Northwest Agriculture & Forestry University, Yangling, Shaanxi Province 712100, People''s Republic of China;3. Jinghua Pharmaceutical Group Co., Ltd., Nantong, Jiangsu Province, 226005, People''s Republic of China;1. School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People''s Republic of China;2. Henan Key laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, People''s Republic of China;3. College of Chemistry and Chemical Engineering, Xuchang University, Henan, Xuchang 461000, People''s Republic of China;1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People''s Republic of China;2. Changzheng Hospital, Second Military Medical University, Shanghai 200003, People''s Republic of China;3. Department of Cell Biology, Second Military Medical University, Shanghai 200433, People''s Republic of China |
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| Abstract: | Six allo-cedrane sesquiterpenes, four seco-prezizaane-type sesquiterpenes, two monocyclofarnesane sesquiterpenes, together with four known sesquiterpenes, were isolated from the roots of Illicium dunnianum. The structures were elucidated by spectroscopic methods including 1D and 2D NMR. The absolute configuration of 10 was determined by a CD experiment. Compounds 11 and 13 showed potent activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor in vitro, with IC50 values of 2.10 ± 0.40 and 1.93 ± 0.57 μM, respectively. All compounds were evaluated for cytotoxicities against five human cancer cell lines (A549, Bel-7402, BGC-823, HCT-8, and A2780) in the MTT assay, but none of them exhibited activity at concentrations tested (10−5–10−7 M). |
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