Indole alkaloids from Ervatamia chinensis |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China;2. College of Life Sciences, Guizhou University, Guiyang 550025, People’s Republic of China;1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China;2. Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, People’s Republic of China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;4. First College of Clinical Medical Science of China, Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, People’s Republic of China;1. Laboratoire EIMS UMR 241 EIO, Université de la Polynésie française, BP 6570, 98702 Faa’a, Tahiti, French Polynesia;2. Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain;3. Laboratoire ITODYS UMR CNRS 7086, Université Paris Diderot, Sorbonne Paris Cité, 15 rue J.-A. de Baïf, 75013 Paris, France;4. Université de Versailles Saint Quentin en Yvelines, 55 Avenue des Etats-Unis, 78035 Versailles Cedex, France;5. Laboratoire d’Excellence “CORAIL” – Centre de Recherches Insulaires et Observatoire de l’Environnement (CRIOBE), BP 1013 – 98729, Papetoai, Moorea, French Polynesia;6. MPI for Chemical Ecology, Hans-Knöll-Strasse 8, 07745 Jena, Germany;7. Institut de Chimie de Nice-PCRE, UMR 7272 CNRS, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France;8. Institut Méditerranéen de Biodiversité et d?Ecologie marine et continentale, UMR 7263 CNRS – IRD – Aix-Marseille Université – UAPV, Station Marine d?Endoume, Rue de la Batterie des Lions, 13007 Marseille, France;1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil;2. Laboratoire d’Hétérochimie Organique, IRCOF-INSA de Rouen, Pl. E. Blondel, BP 08, 76131 Mont-Saint-Aignan cedex, France;1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China;2. College of Life Science, Lanzhou University, Lanzhou 730000, People’s Republic of China;3. School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, People’s Republic of China;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan;2. Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh;3. Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh |
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| Abstract: | Four vobasinyl–ibogan type bisindole alkaloids, ervachinines A–D (1–4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1–4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1–6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. |
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