Triterpene saponins from Antonia ovata leaves |
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| Institution: | 1. Laboratoire de Pharmacognosie, Institut de Chimie Moléculaire de Reims, UMR CNRS 6229, IFR 53 Biomolécules, Bâtiment 18, BP 1039, 51687 Reims cedex 2, France;2. Laboratoire de Biologie cellulaire, Génétique et Histologie, IFR 53 Biomolécules, UFR de Médecine, 51 rue Cognacq-Jay, 51095 Reims cedex, France;3. USR CNRS-Pierre Fabre N° 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France;4. UMR CNRS 6237, IFR 53 Biomolécules, UFR de Médecine, 51 rue Cognacq-Jay, 51095 Reims cedex, France;5. IRD, UMR SAE 138, BP 529, Papeete, 98713 Tahiti, Polynésie Française, France;1. Department of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Hőgyes Endre u 9, Budapest 1092, Hungary;2. Institute of Biology, Department of Plant Anatomy, L. Eötvös University, Pázmány Péter sétány 1/C, Budapest 1117, Hungary;1. Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur 613 401, Tamil Nadu, India;2. PG Department of Biotechnology, Nehru Memorial College (Autonomous), Puthanampatti 621 007, Tiruchirappalli Dt, Tamil Nadu, India;1. ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;2. Laboratoire de Chimie Organique Biologique, 01 BPV 34 Abidjan 01, Université Félix-Houphouët Boigny d’Abidjan-Cocody, Cote d’Ivoire;3. ICMR-UMR CNRS 7312, Service Commun d’Analyses, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;2. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;3. Institute of Chinese Material Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;1. Department of Horticulture, Faculty of Agriculture, Shahid Bahonar University, P.O. Box 76169133, Kerman, Iran;2. Institute of Genetic Engineering and Biotechnology, P.O. Box 14155-6343, Tehran, Iran;3. Laboratoire d’Ecologie, Systématique et Evolution (ESE), CNRS AgroParisTech-UMR 8079, Université de Paris-Sud (XI), Campus Orsay – Vallée Voie de la faculté, F-91405 Orsay Cedex, France |
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| Abstract: | Six pentacyclic triterpenoid saponins, named antoniosides E–J along with two known alkaloids, were isolated from the leaves of Antonia ovata. Their structures were determined by the extensive use of 1D and 2D-NMR experiments along with HRESIMS analysis and acid hydrolysis. All isolated saponins contained the same pentasaccharide chain: 3-O-β-d-glucopyranosyl-(1 → 2)]-β-d-glucopyranosyl-(1 → 4)]-β-d-glucopyranosyl-(1 → 3)-α-l-arabinopyranosyl(1 → 6)]-β-d-glucopyranoside, linked at C-3 of esterified derivatives of polyhydroxyoleanene triterpenoids (theasapogenol A and 15α-hydroxy-theasapogenol A). Isolated compounds were evaluated for their cytotoxic activity against KB cell line by a WST-1 assay, and the IC50 values ranged from 3.3 to 5.3 μM. |
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