Alkaloids from Melodinus yunnanensis |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, PR China;3. Department of Biochemistry, Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaound, Cameroon;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan;2. Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10500, Thailand;1. School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China;2. Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China;1. School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China;2. Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Jinan 250014, PR China;3. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, PR China;1. Faculty of Agriculture and Food, Kunming University of Science and Technology, Kunming, 650500, China;2. Department of Chemistry, Liaocheng University, Liaocheng, 252059, China;3. Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650000, China;4. Engineering Research Center of Biopolymer Functional Materials of Yunnan, Yunnan Minzu University, Kunming, 650500, China;5. Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan |
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| Abstract: | Ten monoterpenoid indole alkaloids, namely meloyine, 19S-methoxytubotaiwine N4-oxide, 16,19-epoxy-Δ14-vincanol, 14β-hydroxymeloyunine, meloyunine, Δ14-vincamenine N4-oxide, 16β,21β-epoxy-vincadine, 14β,15β-20S-quebrachamine, 3-oxo-voaphylline, 2α,7α-dihydroxy-dihydrovoaphylline, and 32 known alkaloids were isolated from leaves and twigs of Melodinus yunnanensis. Their structures were elucidated based on 1- and 2-D NMR, FTIR, UV, and MS spectroscopic data. Meloyine I showed weak cytotoxic activity against four human cancer cell lines: MCF-7 breast cancer, SMMC-7721 hepatocellular carcinoma, HL-60 myeloid leukemia, and A-549 lung cancer. |
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