Integrated influence of environmental factors on the state of microcirculation

The microcirculation system and its regulation at rest and after gradually growing physical activity in subjects living in different environmental regions was studied using laser Doppler flowmetry. Three main types of microcirculation were found. The activity of regulation mechanisms depended on the microcirculation type, residence region, and level of physical activity. Subjects living in relatively clean regions displayed stable regulation mechanisms irrespective of the level of activity. Subjects with the mesoemic type of microcirculation from regions with a high toxic contamination, high radiation background, or exposed to combined adverse factors, as well as subjects with the hypoemic type exposed to toxic and combined factors displayed a decreased contribution of VLF and LF oscillations (p < 0.05), and subjects with the hyperemic type from toxically contaminated regions displayed a decreased contribution of LF oscillations (p < 0.05). The results indicate that, under environmental pressure, regulatory mechanisms are exerted to the extent verging on adaptation failure.