Abnormalities in erythrocyte membrane band 3 in chronic myelogenous leukemia |
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| Authors: | M Kundu J Basu M M Rakshit P Chakrabarti |
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| Affiliation: | Department of Chemistry, Bose Institute, India. |
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| Abstract: | The anion transport activities of erythrocytes from patients with chronic myelogenous leukemia (CML) and normal donors were comparable. In CML erythrocytes, significant reduction in the number of ankyrin-binding sites, present in the cytoplasmic domain of band 3, may lead to partial loss of cytoskeletal anchorage to the bilayer and account for their increased Con-A agglutinability and heat-sensitivity (Basu, J., Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945, 121-126). |
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