Sequence of the ebgA gene of Escherichia coli: comparison with the lacZ gene |
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Authors: | H W Stokes P W Betts B G Hall |
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Institution: | Molecular and Cell Biology Department, University of Connecticut, Storrs 06268. |
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Abstract: | We have sequenced the ebgA (evolved beta-galactosidase) gene of Escherichia
coli K12. The sequence shows 50% nucleotide identity with the E. coli lacZ
gene, demonstrating that the two genes are related by descent from a common
ancestral gene. Comparison of the two sequences suggests that the ebgA gene
has recently been under selection. A significant excess of identical,
rather than synonymous, codons used to encode identical amino acids at the
same positions in the aligned sequences implies that some form of selection
is operating directly at the DNA level. This selection is independent of,
and in addition to, selection based on codon usage or on function of the
gene products.
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