Determination of trans-resveratrol in human plasma by high-performance liquid chromatography |
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Authors: | Zhimeng Zhu Gia Klironomos Andre Vachereau Len Neirinck David W Goodman |
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Institution: | Pharmascience, 8400 Darnley Road, Montreal, Quebec H4T 1M4, Canada |
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Abstract: | The first method using high-performance liquid chromatography (HPLC) has been developed for the determination of trans-resveratrol in human plasma. The method involves a liquid–liquid extraction followed by reversed-phase HPLC with UV detection. The detection limit of trans-resveratrol in human plasma was 5.0 ng/ml. Standard curves are linear over the concentration range of 5.0–5000.0 ng/ml. Intra-assay variability ranged from 1.9 to 3.7% and inter-assay variability ranged from 2.5 to 4.0% at the concentration range of 15.0–4000.0 ng/ml. |
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Keywords: | trans-Resveratrol |
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