Rapid isolation of moderate and highly polymorphic DNA fragments mapping close to WT (Wilms' tumour) and AN2 (aniridia) on chromosome 11 |
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Authors: | Patricia A Boyd Sheila Christie Nicholas D Hastie David J Porteous |
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Institution: | (1) MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, UK;(2) Present address: Department of Bioscience and Biotechnology, Biology Division, Todd Centre, Strathclyde University, 31 Taylor Street, G4 ONR Glasgow, UK |
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Abstract: | Summary Genes implicated in the development of Wilms' tumour (WT) and aniridia (AN2) have been localised to a subregion of band p13
on chromosome 11 by molecular and cytogenetic characterisation of WAGR syndrome patients carrying variable constitutional
deletions. Polymorphic markers for the region would be valuable for linkage analysis in the familial forms of both Wilms'
tumour and aniridia, as well as for studying somatic rearrangements of chromosome 11 in a variety of tumour types. Here we
describe the isolation and characterisation of three frequently polymorphic arbitrary DNA fragments that map proximal to the
AN2 and WT loci. |
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Keywords: | |
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