HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome. |
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| Authors: | P F Wang M-H Tan C Zhang H Morreau B T Teh |
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| Affiliation: | Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA. |
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| Abstract: | Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions. |
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