生物法生产2,3-丁二醇研究进展

2,3-丁二醇是一种重要的化工原料，可广泛应用于多个领域。二战期间由于合成橡胶需要大量1,3-丁二烯，2,3-丁二醇生产空前发展。近年来，由于聚对苯二甲酸丁烯树脂、γ-丁内酯，Spandex弹性纤维及其前体的需求增长，2,3-丁二醇的需求和产量也稳步增长。多年来，生物法生产2,3-丁二醇虽然得到了广泛的研究，但一直没有实现工业化。本文从产生2,3-丁二醇的菌种及2,3-丁二醇的生理意义、代谢途径、旋光异构体的形成机理、影响发酵的因素与产物的提纯等方面对生物法生产2,3-丁二醇进行了综述并提出了生物法生产2,3-丁二醇要解决的几个问题。

Research Progress of 2,3-butanediol Production by Biological Method

2,3-butanediol(2,3-BD) is an important chemical intermediate and can be used in many fields. 2,3-BD production come to a peak during World War Ⅱ because 1,3-butanediene used for synthetic rubber production could be made from 2,3-BD. Due to the increased demand for polybutylene terephthalate resin, gamma-butyrolactone, spandex and their precursors, the demand and yield of 2,3-BD increased stably in recent years. Although 2,3-BD production by fermentation has been studied widely for many years, its industrialization did not realized till now. The microbe species and the physiological function of 2,3-BD to cell，metabolic pathway, mechanism of stereoisomers formation, the factors influencing the fermentation and downstream recovery of 2,3-BD is discussed, and some problems should be solved in 2,3-BD production is also presented in this article.