JMJD6在胃癌组织中的表达及意义 |
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引用本文: | 李晓伟,许冰,刘剑,殷继鹏,尚鑫,夏丽敏,吴开春.JMJD6在胃癌组织中的表达及意义[J].现代生物医学进展,2015,15(14):2621-2624. |
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作者姓名: | 李晓伟 许冰 刘剑 殷继鹏 尚鑫 夏丽敏 吴开春 |
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作者单位: | 第四军医大学西京消化病医院肿瘤生物学国家重点实验室 |
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基金项目: | 国家973项目(2010CB529302);国家自然科学基金项目(81272652,81172290,91129723) |
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摘 要: | 目的:检测JMJD6蛋白在胃癌组织及相应癌旁正常组织中的表达情况,并分析JMJD6蛋白表达与胃癌患者临床病理参数及预后的关系。方法:应用免疫组织化学方法检测JMJD6蛋白在胃癌组织及相应癌旁正常组织中的表达情况,进一步用Kaplan-Meier生存分析、COX比例风险回归模型等统计学方法研究JMJD6表达与胃癌患者临床病理参数及预后的关系。结果:JMJD6在胃癌组织中的表达阳性率显著高于癌旁正常组织(P=0.001);JMJD6在胃癌组织的高表达与肿瘤临床分期(P=0.008)、病理分级(P=0.001)、局部浸润深度(P=0.028)、有无淋巴结转移(P=0.001)等显著相关;Kaplan-Meier生存分析结果表明JMJD6高表达的胃癌患者术后总体生存率显著低于JMJD6低表达的患者(P=0.023)。结论:JMJD6在胃癌的发生发展中可能发挥了癌基因样作用,可能作为胃癌治疗的潜在靶点。
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关 键 词: | JMJD6 蛋白 胃癌 表达 临床病理特征 |
Expression and Significance of JMJD6 in the Gastric Cancer |
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Abstract: | Objective:To detect the expression of Jumonji domain containing 6 (JMJD6) in gastric cancer (GC) tissues and
adjacent non-tumor tissues, and investigate the significance of JMJD6 in GC.Methods:JMJD6 expression in 90 pairs of GC tissues and
corresponding non-tumor tissues was detected by immunohistochemistry. The correlation of JMJD6 expression with the
clinicopathological characteristics of GC was analyzed by Kaplan-Meier and Cox regression.Results:The expressions of JMJD6 protein
in GC tissues was significantly higher than that in adjacent non-tumor tissues (P=0.001). Further analysis showed that the high expression
of JMJD6 protein in GC tissues was significantly related to the clinical stage (P=0.008), Pathological grade (P=0.001), tumor local
invasion depth (P=0.028), tumor-node-metastasis stage (P=0.001). Kaplan-Meier survival analysis showed that GC patients with a higher
expression of JMJD6 had a poorer prognosis (P=0.023).Conclusion:JMJD6 may act as an oncogene in the initiation and progression of
GC; JMJD6 might be a potential therapeutic target of GC. |
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Keywords: | JMJD6 Gastric Cancer Expression Clinicopathological characteristics |
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