低硒对大鼠心电图的影响及补硒后的变化

目的:探讨低硒对大鼠心电图的影响及补硒后心电图的变化。方法:将30只SD大鼠随机分为对照组、低硒组及补硒组,每组各10只,对照组喂养标准饲料,低硒组喂养低硒饲料,补硒组喂养低硒饲料14周后再给予亚硒酸钠补硒3周,各组喂养17周后,检测大鼠的血硒、血清谷胱甘肽过氧化物酶及心电图的变化。结果:低硒组大鼠血硒水平和血清谷胱甘肽过氧化物酶水平与对照组相比明显降低(P0.05),补硒后两者又明显增加(P0.05)。正常对照组大鼠心电图大部分正常,低硒组大鼠心电图多数为异常心电图,主要表现为室性早搏、室性心动过速、交界性房性早搏、T波低平等,补硒组大鼠心电图大部分恢复正常心电图,仅有少部分表现为异常心电图。结论:低硒可导致大鼠谷胱甘肽过氧化物酶活性减低,低硒饮食后,大鼠心电图明显发生异常,多表现为室性心律失常,补硒可使低硒所致的心电图变化多数恢复正常。

Effects of Low Seleniumon ECG in Rats and the Changes after Selenium Supplement

Objective:To explore the effects of low seleniumon ECG in rats and the changes after seleniumsupplement.Methods:30 SD rats were randomly divided into control group, low selenium group and selenium supplement group, with 10 rats in each group. Rats in the control group were fed with standard diet, rats in the low seleniumgroup were fed with low selenium diet and rats in selenium supplement group were fed with low selenium diet for 14 weeks and then sodium selenite for 3 weeks. Seventeen weeks later, blood selenium, serum glutathione peroxidase and electrocardiograph (ECG) were detected.Results:The levels of blood selenium and serum glutathione peroxidase in low selenium group decreased significantly, compared with that in the control group (P<0.05), but after selenium supplement, both of them increased significantly (P<0.05). The vast majority of ECG of rats in the control group was normal. However, ECG of rats in low selenium group were mostly abnormal, mainly manifested as the ventricular premature beat, ventricular tachycardia, junctional premature atrial contraction, and low equality of T wave. After selenium supplement, most of ECG returned to normal, and only a small part were abnormal.Conclusion:Low selenium can lead to the reduction of glutathione peroxidase activity of rats. Rats with low selenium diet showed significantly abnormal ECG, and more performance for the ventricular arrhythmia. Selenium supplement can make the ECG changes caused by low seleniumcome back to normal.