非酒精性脂肪性肝病与肠粘膜屏障关系的研究进展

近年来,非酒精性脂肪性肝病的发病率正呈逐年升高趋势,且可进一步发展为非酒精性肝炎、肝硬化甚至肝癌,但其具体的发病机制目前尚未完全阐明。迄今为止,关于非酒精性脂肪性肝病较为人们所接受的是"两次打击学说",即肝脏的脂肪变性及脂质的过氧化反应。自"肠-肝轴"被提出后,关于肠道粘膜屏障功能与非酒精性脂肪性肝病的发生和发展的关系备受研究人员的关注。近些年来,关于非酒精性脂肪性肝病与肠道粘膜的机械屏障、生物屏障、化学屏障、免疫屏障方面的研究越来越多,肠粘膜的四个屏障功能与非酒精性脂肪性肝病密切相关,相互影响共同促进疾病的发生发展。本文就非酒精性脂肪性肝病与肠粘膜屏障关系的研究进展进行了综述。

Advances in the Correlation of Non-alcoholic Fatty Liver Disease with Intestinal Mucosal Barrier

The incidence of non-alcoholic fatty liver disease is increasing these years, which can further develop into non-alcoholic hepatitis, cirrhosis and even liver cancer. However, specific pathogenesis has not been fully elucidated yet. So far, "two-hit theory" is more admitted by people concerning the non-alcoholic fatty liver disease, that is steatosis and lipid peroxidation of liver. Since the "gut-liver axis" proposed, researchers have drawn more and more attention to the process of intestinal mucosal barrier participating in non-alcoholic fatty liver disease. Recently, an increasing number of studies related to the correlation of non-alcoholic fatty liver disease with mechanical barrier, biologic barrier, chemic barrier, immune barrier of intestinal mucosa have been reported, the four functions of intestinal mucosal barrier are closely associated with nonalcoholic fatty liver disease, and their interrelationship jointly promotes the occurrence and development of the disease. In this paper, the correlation of non-alcoholic fatty liver disease with intestinal mucosal barrier is mainly reviewed.