胃肠激素与肥胖关系的研究进展

胃肠激素(gastrointestinal hormone)是一类性质不同的具有激素或类激素功能的多肽,这些肽可将胃肠道的信号传递到食欲相关的脑区进行整合,然后沿神经纤维传递到神经末梢进行释放,从而调节细胞活动。胃肠激素在机体的能量稳态平衡中发挥重要调节作用。膳食中三种产能营养素的比例失调或不良的饮食行为会导致机体能量稳态调节失衡。目前研究认为,胃肠激素可能是有效治疗肥胖的新型潜在靶点,但其作用机制尚不清楚。因此,本文对ghrelin、胆囊收缩素(Cholecystokinin,CCK)和胰高血糖素样肽-1(Glucagon peptide-1,GLP-1)三种胃肠激素与肥胖的发生及发展之间关系进行综述。

Research on Correlations of Gastrointestinal Hormones and Calorigenic Nutrients for Obesity

Gastrointestinal hormone is a kind of peptides with hormones or hormone functions that could send signals to the appetite of gastrointestinal-related brain region for integration, and then pass along the nerve fibers to regulate the activities of the cells. Gastrointestinal hormones play the important role of energy homeostasis in the body. Researches have shown that the gastrointestinal hormone may be an effective and potential target for the treatment of obesity. However, it''s unclear that the relationship of gut hormones, calorigenic nutrients and eating behaviors. Therefore, this paper aims to research the correlations of ghrelin, CCK and GLP-1 with obesity.