Isolation and Identification of α-(γ-Aminobutyryl)-Hypusine |
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| Authors: | Akira Sano Kazuhiko Kotani Yasuo Kakimoto |
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| Institution: | Department of Neuropsychiatry, Ehime University, School of Medicine, Shigenobu, Ehime, Japan |
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| Abstract: | A new dipeptide, alpha-(gamma-aminobutyryl)-hypusine, was identified in bovine brain. This compound was isolated from trichloroacetic acid-soluble fraction of bovine brain with five steps of ion-exchange chromatography. Its structure was postulated by routine chemical analyses and determined by synthesis. The amount of the compound isolated from 1.2 kg of bovine brain was 870 nmol. |
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| Keywords: | α-(γ-Aminobutyryl)-hypusine γ-Aminobutyric acid Hypusine |
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