Mitotic activity of gonadotropes in the anterior pituitary of the castrated male rat |
| |
| Authors: | Dr. Kinji Inoue Shigeyasu Tanaka Kazumasa Kurosumi |
| |
| Affiliation: | (1) Department of Morphology, Institute of Endocrinology, Gunma University, Gunma, Japan;(2) Institute of Endocrinology, Gunma University, Maebashi, 371 Gunma, Japan |
| |
| Abstract: | Summary The proliferation of gonadotropes in the anterior pituitary of the castrated male rat was examined immunohistochemically after colchicine treatment. The results show a more than 10-fold increase in mitotic frequency in gonadotropes 1 or 2 weeks after castration, as compared with controls. This result explains the increase in the population of immunoreactive LH cells in castrated male rats. The gonadotropes decreased significantly 1 month after castration. The mitotic activity of gonadotropes was almost completely suppressed in castrates implanted with a silastic tube filled with testosterone. |
| |
| Keywords: | Pituitary Castration Gonadotropes Mitosis Testosterone replacement Rat |
| 本文献已被 SpringerLink 等数据库收录！ |
|
