Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5. |
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| Authors: | L Zhang P M Mohan and R Padmanabhan |
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| Institution: | Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66103. |
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| Abstract: | Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5. |
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