A model system for studying solid phase peptide reactions |
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| Authors: | L C Dorman L D Markley D A Mapes |
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| Affiliation: | 1. Mathematics Department, Faculty of Science, Al-Azhar University, Nasr-City, Cairo, Egypt;2. Engineering School, DEIM, Tuscia University, Viterbo, Italy;3. Tecnológico Nacional de México/CENIDET, Interior Internado Palmira S/N, Col. Palmira, Mexico Universidad Virtual CNCI, Cuernavaca, Morelos, C.P. 62490, Mexico;4. Department of Mathematics, Faculty of Arts and Sciences, Çankaya University, Ögretmenler Cad., Ankara 1406530, Turkey;5. Institute of Space Sciences, Magurele, Bucharest, Romania;7. Department of Mathematics, Faculty of Science, Cairo University, Giza 12613, Egypt |
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| Abstract: | ![]()
A model system has been devised for studying solid-phase peptide reactions. The system is based on the stepwise solid-phase synthesis of l-leucyl-l-alanylglycyl-l-valine starting from BOC-l-valine resin ester. The eight possible components—valine, six shorter peptide fragments, and the tetrapeptide—of this system can be determined quantitatively with an automatic amino acid analyzer.This model system can be utilized to evaluate different resins, reagents, and reactions (racemization-free) for use in solid-phase peptide synthesis. |
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