2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors |
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| Authors: | Hyup Yung Hyup Kwan Jin Kwan Kang Seon-Hwa Noh Min-Soo Ha Jun-Yong Kyu Jin Kyu Min Kyung Min Hoon Chang Hoon Chung Shin |
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| Affiliation: | Drug Discovery, AmorePacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@pacific.co.kr |
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| Abstract: | ![]()
A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity. |
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