The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma |
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| Authors: | E V Inzhevatkin A A Savchenko |
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| Institution: | 1.Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS,Krasnoyarsk,Russia;2.Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”,Krasnoyarsk,Russia |
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| Abstract: | In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures. |
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