Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents |
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| Authors: | Tandon Vishnu K Yadav Dharmendra B Chaturvedi Ashok K Shukla Praveen K |
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| Institution: | Department of Chemistry, Lucknow University, Lucknow 226007, India. vishnutandon@yahoo.co.in |
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| Abstract: | A series of (1,4)-naphthoquinono 3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats. |
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