In vivo binding of [18F]GBR 13119 to the brain dopamine uptake system |
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| Authors: | M R Kilbourn |
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| Institution: | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109. |
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| Abstract: | Regional rat brain uptake of 18F]GBR 13119, a high specific activity, positron-emitter labeled derivative of the potent dopamine uptake antagonist GBR 12935, is reported. Striatum to cerebellum ratios of 3 are obtained at 90 minutes post injection. Specific binding in striatum can be blocked by pretreatment with dopamine uptake system antagonists (mazindol, nomifensine) but not with receptor antagonists (spiperone, flupenthixol). 18F]GBR 13119 is proposed as a new positron-emitting radioligand for in vivo PET studies of the pre-synaptic dopamine uptake system. |
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