| 乌拉坦对青、老年猫视皮层神经元反应特性的影响(英文) |
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| 作者姓名： | Peng QS Zhou J Shi XM Hua GP Hua TM |
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| 作者单位： | 安徽师范大学生命科学学院,安徽芜湖,241000 |
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| 基金项目： | Supported by Natural Science Foundation of Anhui Province (070413138); the Key Research Foundation of Anhui Province Education Department (KJ2009A167) |
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| 摘 要： | 以前的电生理研究结果显示, 老年哺乳动物视皮层细胞的自发反应及对视觉刺激的诱发反应比青年动物的显著增加, 而对光栅刺激的方位和运动方向选择性却显著下降。然而, 这种视皮层细胞功能的老年性改变是否因青、老年猫细胞对不同麻醉水平的敏感性差异引起尚不清楚。为探讨该问题, 以常用的麻醉药——乌拉坦(Urethane)为实验对象, 通过改变其麻醉剂量分别记录青、老年猫初级视皮层细胞对不同方位和运动方向光栅刺激的调谐反应。研究结果显示, 在基础麻醉量的基础上, 累积增加 50 mg 和 100 mg 乌拉坦对青、老年猫视皮层细胞的自发反应和诱发反应以及对光栅刺激方位和运动方向的选择性不产生显著影响, 累积增加 150 mg 乌拉坦会导致青、老年猫视皮层细胞对视觉刺激的反应性下降, 但下降的幅度相似。以上研究结果表明, 不同剂量的乌拉坦对青、老年动物视皮层细胞的反应性具有相似的影响。
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| 关 键 词： | 乌拉坦 麻醉影响 初级视皮层 神经元反应特性 青年猫 老年猫 |
Effects of urethane on the response properties of visual cortical neurons in young adult and old cats |
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| Peng QS,Zhou J,Shi XM,Hua GP,Hua TM.Effects of urethane on the response properties of visual cortical neurons in young adult and old cats[J].Zoological Research,2011,32(3):337-342. |
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| Authors: | Peng Qing-Song Zhou Jun Shi Xia-Ming Hua Guo-Peng Hua Tian-Miao |
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| Institution: | PENG Qing-Song,ZHOU Jun,SHI Xia-Ming,HUA Guo-Peng,HUA Tian-Miao*(School of Life Science,Anhui Normal University,Anhui Wuhu 241000,China) |
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| Abstract: | Previous studies have shown that visual cortical neurons in old mammals exhibit higher spontaneous activity,higher responsiveness to visual stimuli,and lower selectivity for stimulus orientations and motion directions than did neurons in young adult counterparts.However,whether the responsive difference in cortical neurons between young and old animals resulted from different effects induced by anesthetics has remained unclear.To clarify this issue,we recorded the response properties of individual neurons i... |
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| Keywords: | Urethane Anesthesia effects Neuronal response properties Primary visual cortex Young adult cats Old cats |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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