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Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
Authors:Kevin H. Lin  Abigail Xie  Justine C. Rutter  Yeong-ran Ahn  Julia M. Lloyd-Cowden  Amanda G. Nichols  Ryan S. Soderquist  Timothy R. Koves  Deborah M. Muoio  Nancie J. MacIver  Jatinder K. Lamba  Timothy S. Pardee  Chad M. McCall  David A. Rizzieri  Kris C. Wood
Affiliation:1. Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA;2. Department of Medicine, Duke University Medical Center, Durham, NC, USA;3. Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest Baptist Health, Winston-Salem, NC, USA;4. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA;5. Department of Pediatrics, Duke University Medical Center, Durham, NC, USA;6. Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA;7. Department of Pathology, Duke University Medical Center, Durham, NC, USA
Abstract:
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  • Keywords:Corresponding author  acute myeloid leukemia  genetic screens  CRISPR  cancer metabolism  mitochondria  heme biosynthesis  apoptosis
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