Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue |
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| Authors: | Kojima Naoshi Sugino Maiko Mikami Akiko Nonaka Ken Fujinawa Yumi Muto Isamu Matsubara Kenichi Ohtsuka Eiko Komatsu Yasuo |
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| Affiliation: | Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology, AIST, 2-17-2-1 Tsukisamu-Higashi, Sapporo 062-8517, Japan. |
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| Abstract: | We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleotides in comparison with conventional amino-modification. |
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