Biologically meaningful expression profiling across species using heterologous hybridization to a cDNA microarray |
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Authors: | Susan CP Renn Nadia Aubin-Horth Hans A Hofmann |
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Affiliation: | (1) Harvard University, Bauer Center for Genomics Research, 7 Divinity Avenue, 02138 Cambridge, MA, USA |
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Abstract: | Background Unravelling the path from genotype to phenotype, as it is influenced by an organism's environment, is one of the central goals in biology. Gene expression profiling by means of microarrays has become very prominent in this endeavour, although resources exist only for relatively few model systems. As genomics has matured into a comparative research program, expression profiling now also provides a powerful tool for non-traditional model systems to elucidate the molecular basis of complex traits. |
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