(1) Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, 14263 Buffalo, New York, USA
Abstract:
Background
Examination of ancient gene families can provide an insight into how the evolution of gene structure can relate to function.
Functional homologs of the evolutionarily conserved transforming acidic coiled coil (TACC) gene family are present in organisms from yeast to man. However, correlations between functional interactions and the evolution
of these proteins have yet to be determined.