Molecular neurobiology and pharmacology of the Vasopressin/Oxytocin receptor family |
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| Authors: | J Peter H Burbach Roger A H Adan Stephen J Lolait Fred W van Leeuwen Eva Mezey Miklos Palkovits Claude Barberis |
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| Institution: | (1) Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands;(2) Laboratory of Cell Biology National Institute of Mental Health, 20892 Bethesda, MD;(3) Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands;(4) Clinical Neuroscience Branch, National Institute of Neurological Diseases and Stroke, 20892 Bethesda, MD;(5) Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Rue de la Cardonille, 34094 Montpellier Cedoc 5, France |
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| Abstract: | Summary 1. VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors.2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor.3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed. |
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| Keywords: | vasopressin oxytocin G-protien coupled receptors |
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