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Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a |
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| Authors: | Tommaso Mazza Stefano Castellana Angelo Andriulli Charles Auffray Manlio Vinciguerra Valerio Pazienza |
| Affiliation: | 1. Bioinformatics Unit, IRCCS “Casa Sollievo della Sofferenza” – Mendel Laboratory, Rome, Italy;2. Gastroenterology Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, FG, Italy;3. European Institute for Systems Biology & Medicine, CNRS-UCBL-ENS, Université de Lyon, France;4. UCL – Institute for Liver and Digestive Health, Division of Medicine, Royal Free Hospital, London, United Kingdom;5. Istituto EuroMEditerraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy |
| Abstract: | Chronic hepatitis C patients display many genotype-specific clinical features of HCV infection. The core proteins encoded by different genotypes dysregulate numerous sets of distinct host genes. In this study we tested the hypothesis that HCV core proteins 1b and 3a would actually act on a limited number of independent cellular players, as well as on several functionally linked gene products. Structural and functional tests identified a core set of host genes dysregulated by HCV core genotypes 1b and 3a. The core proteins of HCV genotypes 1b and 3a target specifically limited sets of functionally related gene products, which may be responsible for the variations in the clinical spectra associated with HCV infection. |
| Keywords: | System biology HCV core protein |
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