Reduced renal cortical ribonucleoside triphosphate pools in three different hypophosphatemic animal models

Renal cortical metabolite quantitation in three different models of hypophosphatemia demonstrates that ribonucleoside triphosphate depletion is a common manifestation of reduced plasma phosphate concentration. Total tissue inorganic phosphate is not necessarily altered as the result of hypophosphatemia. Compensatory increases in mono- and diphosphate pools maintain the total ribonucleotide pool but cause reductions in the energy charge for the adenine, guanine, and uridine nucleotides. The coordinate regulation of all ribonucleoside triphosphate pools suggests cellular dysfunction accompanying hypophosphatemia may be the consequence of a generalized derangement in energy and nucleotide metabolism.