Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats |
| |
| Authors: | Kawakubo Keishi Akiba Yasutada Adelson David Guth Paul H Engel Eli Taché Yvette Kaunitz Jonathan D |
| |
| Institution: | Digestive Diseases Division, CURE: Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles, CA 90073, USA. |
| |
| Abstract: | RX 77368 (RX) increases gastric mucosal blood flow by a vagal cholinergic mechanism. The relative roles of mucosal and connective tissue mast cells (MMC and CTMC) were investigated in RX-injected rats. Blood flow and mast cell degranulation were measured after intracisternal RX. RX significantly increased gastric mucosal blood flow, and sequentially degranulated CTMC and MMC. Ketotifen or doxantrazole inhibited the hyperemic response. Ondansetron, RS-039604-90, or famotidine, but not ketanserin or pyrilamine, reduced hyperemia. Mast cells mediate RX-induced gastric hyperemia via 5-HT3, 5-HT4, and H2 receptors; initial increase depends upon CTMC whereas MMC contributes to the later response. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
