Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals |
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Authors: | Haseeb A. Khan Samia H. Sobki Aishah Ekhzaimy Isra Khan Mona A. Almusawi |
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Affiliation: | 1. Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;2. Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia;3. Division of Endocrinology, Department of Medicine, King Khalid University Hospital, Riyadh 12372, Saudi Arabia;4. Rohilkhand Medical College and Hospital, Bareilly 243006, India;5. Department of Family and Community Medicine, Faculty of Medicine, King Saud University, Riyadh 12372, Saudi Arabia |
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Abstract: | Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM). We determined the homeostatic model assessment insulin resistance (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in T2DM patients and non-diabetic subjects. This study comprised a total of 47 T2DM patients and 38 non-diabetic controls. Venous blood samples from all the subjects were collected and sera were analyzed for FBG, HbA1c, insulin and C-peptide using an autoanalyzer. HOMA-IR was calculated using the following equation: HOMA-IR?=?fasting insulin (µU/ml)?×?fasting glucose (mmol/L)/22.5. There was a significant increase in the levels of FBG and HbA1c in diabetic patients. Although the levels of C-peptide and insulin did not differ significantly between the two groups, a significant increase in HOMA-IR was observed in T2DM patients. Both insulin and C-peptide were significantly correlated with HOMA-IR. In conclusion, C-peptide may serve as a simple and convenient predictor of HOMA-IR. |
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Keywords: | Insulin resistance Diabetes C-peptide Fasting blood glucose HbA1c Biomarker |
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