SCD1 promotes lipid mobilization in subcutaneous white adipose tissue |
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| Authors: | Ying Zou Yi-Na Wang Hong Ma Zhi-Hui He Yan Tang Liang Guo Yang Liu Meng Ding Shu-Wen Qian Qi-Qun Tang |
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| Institution: | 1.Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology of the School of Basic Medical Sciences, and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai Medical College, Shanghai, China;2.Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Institutes of Biomedical Sciences, Fudan University, Shanghai, China |
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| Abstract: | Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1’s products, oleic acid (OA). OA upregulated adipose TAG lipase and hormone-sensitive lipase expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation were increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in upregulating lipid mobilization through its desaturation product, OA. |
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| Keywords: | stearoyl-CoA desaturase-1 triacylglycerol adipocytes lipolysis lipophagy oleic acid thermogenesis |
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